Characterization of Novel HIV-1 Intersubtype CRF01_AE/C and A1/C Recombinants from India

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Characterization of Novel HIV-1 Intersubtype CRF01_AE/C and A1/C Recombinants from India

We report here three novel HIV-1 intersubtype recombinants from India. One among those is a recombinant between subtype C and CRF01_AE and another two between A1 and C. A recombinant virus with CRF01_AE is reported for the first time from India.

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Retroviruses are highly recombinogenic, but recombination can only occur between genomes packaged within the same virion. Until about 1994, it was generally thought that individuals do not become infected with multiple distinct HIV-1 strains, and so the possibility that recombination between divergent viruses could contribute to the evolution of HIV-1 was not widely considered. However, not lon...

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ژورنال

عنوان ژورنال: Genome Announcements

سال: 2015

ISSN: 2169-8287

DOI: 10.1128/genomea.00849-15